Nanocarriers for Successful Drug Delivery Across Blood-Brain Barrier

  • Sara Salatin Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran


The blood-brainbarrier (BBB) is a highly selective semipermeable boundary between neural tissue and bloodstream. The unique and protective features of the BBB has a key role in maintaining brain homeostasis as well as ion and molecule exchange. The neurodegenerative diseases such as stroke, multiple sclerosis, brain tumors, Parkinson's, and Alzheimer's disease can lead to BBB dysfunction. However, in a damaged and more permeable BBB, drug delivery into the brain is still a big challenge. Nanoparticulate drug delivery systems are able to encapsulate drug molecules and mediate drug passage across the BBB in neuronal pathologies by targeting specific transport processes in the brain vasculature. In this mini review, we will highlight nanoparticulate delivery systems used to deliver drugs across the BBB as well as the factors affecting their transportation after systemic administration.

Mini Review Article